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Vaccine Detail
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Brucella melitensis Hia subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella melitensis Hia subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009279
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Goat
- Host Species as Laboratory Animal Model: Mus musculus; Capra hircus; Homo sapiens; Escherichia coli
- Antigen: Hia
- Preparation: Recombinant expression of selected outer membrane proteins (Omp22, Hia, BtuB, FlgK) was performed for validation. (Gomez et al, 2013)
- Description: A multi-step antigen selection approach was used to identify outer membrane proteins of Brucella melitensis 16M with antigenic determinants for potential vaccine formulation. Efficacy: Not reported; studies to assess immunogenicity and protective efficacy of individual proteins in mice are currently underway. Immune response: Omp22 and Hia showed high adhesin probability and conferred invasive capacity; all proteins except FlgK reacted with sera from exposed hosts; BtuB, Hia, and FlgK stimulated mixed Th1-Th2 responses in mouse splenocytes; BtuB and Hia elicited nitric oxide release from splenocytes of S19 immunized mice. (Gomez et al, 2013)
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| Host Response |
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| References |
Gomez et al, 2013: Gomez G, Pei J, Mwangi W, Adams LG, Rice-Ficht A, Ficht TA. Immunogenic and invasive properties of Brucella melitensis 16M outer membrane protein vaccine candidates identified via a reverse vaccinology approach. PloS one. 2013; 8(3); e59751. [PubMed: 23533646].
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