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Vaccine Detail
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live attenuated Brucella abortus strain 19-RB6 vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain 19-RB6 vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009273
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: wboA gene deletion
- Preparation: Live attenuated rough mutant with wboA gene deletion. (Wang et al, 2013)
- Description: Constructed as a rough-mutant strain with wboA gene deletion from Brucella abortus strain S19 parent strain to evaluate effects of genetic background on virulence, pathogenicity, and protective immunity. Efficacy: Shorter survival time in mice (less than 6 weeks) but offered better protection against Brucella abortus 2308 challenge than some other mutants; did not induce abortion in pregnant sheep. Immune response: Induced protective immunity not directly correlated with survival time in vivo; effective in inducing protection against homologous challenge. (Wang et al, 2013)
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| Host Response |
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| References |
Wang et al, 2013: Wang Z, Niu J, Wang S, Lv Y, Wu Q. In vivo differences in the virulence, pathogenicity, and induced protective immunity of wboA mutants from genetically different parent Brucella spp. Clinical and vaccine immunology : CVI. 2013 Feb; 20(2); 174-80. [PubMed: 23239800].
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