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Vaccine Detail
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live attenuated Brucella abortus strain 19 virB5 gene deletion mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain 19 virB5 gene deletion mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009257
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: virB5 gene deletion
- Description: A gene deletion mutant strain of Brucella abortus strain 19 with virB5 deletion was constructed as a molecular tag vaccine. Immune response: Recombinant VirB5 antigen could discriminate mice infected with wild-type B. abortus from those infected with the virB5 mutant strain, indicating potential as a serological marker. (Tan et al, 2012)
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| Host Response |
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| References |
Tan et al, 2012: Tan W, Wang XR, Nie Y, Wang C, Cheng LQ, Wang XC, Zhang R, Yan GM. Recombinant VirB5 protein as a potential serological marker for the diagnosis of bovine brucellosis. Molecular and cellular probes. 2012 Jun; 26(3); 127-31. [PubMed: 22662340].
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