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Vaccine Detail
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live attenuated Brucella melitensis strain M5-90 vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis strain M5-90 vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009248
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Goat
- Host Species as Laboratory Animal Model: Mus musculus
- Preparation: Live attenuated strain derived from B. melitensis strain M28 (Wang et al, 2011)
- Description: B. melitensis strain M5-90 is a live attenuated vaccine cultured from B. melitensis strain M28 and has been used as an effective tool in the control of brucellosis in goats and sheep in China. Efficacy: Not directly reported; study provides molecular insights into attenuation mechanisms that may facilitate generation of new attenuated vaccine strains with enhanced efficacy Immune response: Infection induced parallel changes in gene expression profiles in macrophages, including induction of anti-inflammatory and antiapoptotic factors; differential expression of genes involved in lysosome and MAPK pathways; apoptosis-related genes were key differentially expressed genes in significant pathways (Wang et al, 2011)
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| Host Response |
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| References |
Wang et al, 2011: Wang F, Hu S, Liu W, Qiao Z, Gao Y, Bu Z. Deep-sequencing analysis of the mouse transcriptome response to infection with Brucella melitensis strains of differing virulence. PloS one. 2011; 6(12); e28485. [PubMed: 22216095].
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