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Vaccine Detail
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Brucella abortus bp26 and trigger factor DNA vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus bp26 and trigger factor DNA vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009244
- Type: DNA vaccine
- Status: Research
- Host Species for Licensed Use: Buffalo
- Antigen: bp26; trigger factor (TF)
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Adjuvant:
CpG
- Preparation: DNA vaccines encoding bp26 and TF administered intramuscularly with CpG adjuvant at weeks 0, 2, and 4. (Clapp et al, 2011)
- Description: Bison were vaccinated with eukaryotic DNA expression vectors encoding Brucella periplasmic protein bp26 and chaperone protein trigger factor (TF) to understand immune responses in wildlife where current vaccines are ineffective. Efficacy: DNA-vaccinated bison developed enhanced antibody, proliferative T cell, and IFN-γ responses compared to controls; increased percentages of CD4(+) and CD8(+) T lymphocytes observed. Immune response: Strong cellular immune responses indicated by elevated antibody production, T cell proliferation, and interferon-gamma secretion upon antigen restimulation; increased CD4(+) and CD8(+) T cell populations. (Clapp et al, 2011)
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| Host Response |
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| References |
Clapp et al, 2011: Clapp B, Walters N, Thornburg T, Hoyt T, Yang X, Pascual DW. DNA vaccination of bison to brucellar antigens elicits elevated antibody and IFN-γ responses. Journal of wildlife diseases. 2011 Jul; 47(3); 501-10. [PubMed: 21719815].
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