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Vaccine Detail
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live attenuated Brucella abortus strain RB51-leuB vaccine over-expressing SOD |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain RB51-leuB vaccine over-expressing SOD
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009235
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Pig
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: Cu/Zn superoxide dismutase (SOD)
- Preparation: Strain RB51leuB with an antibiotic-resistance marker free plasmid over-expressing SOD. (Rajasekaran et al, 2011)
- Description: A recombinant Brucella abortus strain RB51 leucine auxotroph was engineered to over-express SOD alone to protect against Brucella suis infection. Efficacy: Significant protection compared to control; less effective than the strain over-expressing SOD and WboA. Immune response: Elicited protective immune responses against brucellosis. (Rajasekaran et al, 2011)
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| Host Response |
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Mouse Response
- Immune Response: Elicited protective immune responses against brucellosis. (Rajasekaran et al, 2011)
- Challenge Protocol: Protection efficacy was tested in mice challenged with virulent Brucella suis. (Rajasekaran et al, 2011)
- Efficacy: Significant protection compared to control; less effective than the strain over-expressing SOD and WboA. (Rajasekaran et al, 2011)
- Description: Protection efficacy was tested in mice challenged with virulent Brucella suis. (Rajasekaran et al, 2011)
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| References |
Rajasekaran et al, 2011: Rajasekaran P, Surendran N, Seleem MN, Sriranganathan N, Schurig GG, Boyle SM. Over-expression of homologous antigens in a leucine auxotroph of Brucella abortus strain RB51 protects mice against a virulent B. suis challenge. Vaccine. 2011 Apr 12; 29(17); 3106-10. [PubMed: 21376799].
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