• Vaccine Name: live attenuated Brucella neotomae 26-kDa periplasmic protein gamma irradiated vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009231
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Human
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: 26 kDa periplasmic protein
• Preparation: Recombinant B. neotomae rendered non-replicative by gamma-radiation. (Moustafa et al, 2011)
• Description: Recombinant B. neotomae overexpressing a 26 kDa periplasmic protein was evaluated as a vaccine candidate. Efficacy: Vaccinated mice showed significant resistance against challenge with virulent Brucella species. Immune response: Induction of antigen-specific antibody and T cell responses. (Moustafa et al, 2011)

Mouse Response

• Immune Response: Induction of antigen-specific antibody and T cell responses. (Moustafa et al, 2011)
• Challenge Protocol: Immunization of mice followed by challenge with virulent B. abortus, B. melitensis, and B. suis. (Moustafa et al, 2011)
• Efficacy: Vaccinated mice showed significant resistance against challenge with virulent Brucella species. (Moustafa et al, 2011)
• Description: Immunization of mice followed by challenge with virulent B. abortus, B. melitensis, and B. suis. (Moustafa et al, 2011)