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Vaccine Detail
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Brucella abortus gonadotropin releasing hormone subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus gonadotropin releasing hormone subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009213
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Deer
- Antigen: gonadotropin-releasing hormone
- Preparation: Single immunization of either 1,000 microg or 2,000 microg doses of GonaCon. (Killian et al, 2009)
- Description: The vaccine was used to immunize captive female elk to evaluate contraceptive efficacy as a method to reduce brucellosis transmission and manage elk populations. Efficacy: Both doses prevented pregnancy in elk cows for at least three years with infertility rates of 86-100% in treated groups versus 0-28% in controls (P<0.0001). Immune response: Antibody titers were measured but specific immune response details are not reported in the abstract. (Killian et al, 2009)
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| Host Response |
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| References |
Killian et al, 2009: Killian G, Kreeger TJ, Rhyan J, Fagerstone K, Miller L. Observations on the use of GonaCon in captive female elk (Cervus elaphus). Journal of wildlife diseases. 2009 Jan; 45(1); 184-8. [PubMed: 19204347].
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