• Vaccine Name: live attenuated Brucella melitensis strain Rev. 1 bp26 deletion vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009205
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Sheep
• Antigen: bp26 deletion
• Preparation: Live attenuated deletion mutant of Brucella melitensis strain Rev. 1 with bp26 gene deleted; administered subcutaneously or conjunctivally. (Grilló et al, 2009)
• Description: The CGV26 mutant, deleted in the bp26 gene, was tested as a vaccine candidate alternative to the Brucella melitensis strain Rev. 1 vaccine for protection against Brucella ovis infection in sheep. Efficacy: CGV26 conferred significant protection against Brucella ovis, similar to that of Rev. 1 vaccine and significantly higher than the CGV2631 mutant. (Grilló et al, 2009)

Sheep Response

• Challenge Protocol: Efficacy tested in rams challenged with Brucella ovis; comparison of protection conferred by CGV26 versus Rev. 1 and CGV2631 mutants. (Grilló et al, 2009)
• Efficacy: CGV26 conferred significant protection against Brucella ovis, similar to that of Rev. 1 vaccine and significantly higher than the CGV2631 mutant. (Grilló et al, 2009)
• Description: Efficacy tested in rams challenged with Brucella ovis; comparison of protection conferred by CGV26 versus Rev. 1 and CGV2631 mutants. (Grilló et al, 2009)