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Vaccine Detail
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live attenuated Brucella melitensis strain Rev. 1 bp26 and omp31 deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis strain Rev. 1 bp26 and omp31 deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009204
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Antigen: bp26 deletion; omp31 deletion
- Preparation: Live attenuated deletion mutant of Brucella melitensis strain Rev. 1 with bp26 and omp31 genes deleted; administered subcutaneously or conjunctivally. (Grilló et al, 2009)
- Description: The CGV2631 mutant, deleted in both bp26 and omp31 genes, was evaluated as a vaccine candidate against Brucella ovis infection in sheep. Efficacy: CGV2631 conferred significant protection against Brucella ovis but protection was significantly lower than that conferred by CGV26 and Rev. 1 vaccines. (Grilló et al, 2009)
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| Host Response |
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Sheep Response
- Challenge Protocol: Efficacy tested in rams challenged with Brucella ovis; comparison of protection conferred by CGV2631 versus Rev. 1 and CGV26 mutants. (Grilló et al, 2009)
- Efficacy: CGV2631 conferred significant protection against Brucella ovis but protection was significantly lower than that conferred by CGV26 and Rev. 1 vaccines. (Grilló et al, 2009)
- Description: Efficacy tested in rams challenged with Brucella ovis; comparison of protection conferred by CGV2631 versus Rev. 1 and CGV26 mutants. (Grilló et al, 2009)
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| References |
Grilló et al, 2009: Grilló MJ, Marín CM, Barberán M, de Miguel MJ, Laroucau K, Jacques I, Blasco JM. Efficacy of bp26 and bp26/omp31 B. melitensis Rev.1 deletion mutants against Brucella ovis in rams. Vaccine. 2009 Jan 07; 27(2); 187-91. [PubMed: 19007836].
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