• Vaccine Name: Brucella abortus hsp60 subunit vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009202
• Type: Subunit vaccine
• Status: Research
• Antigen: hsp60
• Description: The study suggests that hsp60 is a highly immunogenic heat shock protein produced by Brucella abortus and Brucella melitensis, with higher production in B. abortus. The lower production of hsp60 by B. melitensis may contribute to its greater virulence. The authors propose hsp60 as a good antigenic candidate for engineering a subunit vaccine against Brucella. Immune response: Sera from brucellosis patients reacted strongly with hsp60 and other bacterial proteins, indicating the immunogenicity of hsp60. No reactivity was observed with sera from healthy individuals, suggesting a specific immune response to infection. (Amirmozafari et al, 2008)

Human Response

• Immune Response: Sera from brucellosis patients reacted strongly with hsp60 and other bacterial proteins, indicating the immunogenicity of hsp60. No reactivity was observed with sera from healthy individuals, suggesting a specific immune response to infection. (Amirmozafari et al, 2008)
• Description: Western blotting was used to detect antibody production against bacterial proteins, especially hsp60, using sera from brucellosis patients and healthy individuals. Heat shock was applied to bacterial strains to induce protein expression changes. (Amirmozafari et al, 2008)