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Vaccine Detail
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live attenuated Brucella abortus strain 19 bp26-luciferase omp19 deletion mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus strain 19 bp26-luciferase omp19 deletion mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009199
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: BALB/c mice; Bos taurus (heifers)
- Antigen: omp19 deletion mutant derived from M1-luc
- Preparation: Live attenuated double mutant strain with bp26 replaced by luciferase gene and omp19 deleted. (Fiorentino et al, 2008)
- Description: INTA 2 is a double mutant derived from M1-luc with most of omp19 deleted without introduction of genetic markers. Efficacy: Protection against abortion was 45.5% in heifers vaccinated with INTA 2, lower than S19 and M1-luc; in mice, I2 was more attenuated than S19 with no reduction in protection. (Fiorentino et al, 2008)
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| Host Response |
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| References |
Fiorentino et al, 2008: Fiorentino MA, Campos E, Cravero S, Arese A, Paolicchi F, Campero C, Rossetti O. Protection levels in vaccinated heifers with experimental vaccines Brucella abortus M1-luc and INTA 2. Veterinary microbiology. 2008 Dec 10; 132(3-4); 302-11. [PubMed: 18565697].
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