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Vaccine Detail
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Brucella abortus 60-kDa chaperonin GroEL subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus 60-kDa chaperonin GroEL subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009184
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Antigen: 60-kDa chaperonin GroEL
- Preparation: Identification of immunogenic proteins from B. abortus cell envelope using proteomic techniques including 2-DE, MALDI-TOF MS, and LC-MS/MS; Western blot analyses with sera from infected bovine and human patients identified immunogenic proteins. (Connolly et al, 2006)
- Description: Live attenuated vaccines S19 and RB51 are used to control bovine brucellosis but have safety issues for humans and pregnant cattle; this study aims to identify novel candidate proteins from B. abortus cell envelope for safer vaccine development. Immune response: Several new immunogenic proteins identified by Western blot using antisera from infected bovine and human patients, indicating potential to elicit immune response. (Connolly et al, 2006)
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| Host Response |
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| References |
Connolly et al, 2006: Connolly JP, Comerci D, Alefantis TG, Walz A, Quan M, Chafin R, Grewal P, Mujer CV, Ugalde RA, DelVecchio VG. Proteomic analysis of Brucella abortus cell envelope and identification of immunogenic candidate proteins for vaccine development. Proteomics. 2006 Jul; 6(13); 3767-80. [PubMed: 16739129].
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