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Vaccine Detail
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live attenuated Brucella melitensis asp24 deletion mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis asp24 deletion mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009182
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Goat
- Host Species as Laboratory Animal Model: Capra hircus (pregnant goats); Mus musculus (BALB/c mice)
- Antigen: asp24 deletion mutant
- Preparation: Unmarked deletion mutant live attenuated vaccine strain BMDeltaasp24. (Kahl-McDonagh et al, 2006)
- Description: The vaccine candidate BMDeltaasp24 was evaluated in pregnant goats, the natural host species for Brucella melitensis. Efficacy: BMDeltaasp24 was protective against abortion and infection in the majority of pregnant goats and was more efficacious than BMDeltavirB2 against challenge infection. (Kahl-McDonagh et al, 2006)
The vaccine candidate BMDeltaasp24 is an unmarked deletion mutant evaluated for protection against aerosol challenge. Efficacy: BMDeltaasp24 conferred superior protection to mice against homologous and heterologous aerosol challenge infection. (Kahl-McDonagh et al., 2007)
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Challenge Protocol: Aerosol infection of BALB/c mice followed by homologous and heterologous aerosol challenge. (Kahl-McDonagh et al., 2007)
- Efficacy: BMDeltaasp24 conferred superior protection to mice against homologous and heterologous aerosol challenge infection. (Kahl-McDonagh et al., 2007)
- Description: Aerosol infection of BALB/c mice followed by homologous and heterologous aerosol challenge. (Kahl-McDonagh et al., 2007)
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| References |
Kahl-McDonagh et al, 2006: Kahl-McDonagh MM, Elzer PH, Hagius SD, Walker JV, Perry QL, Seabury CM, den Hartigh AB, Tsolis RM, Adams LG, Davis DS, Ficht TA. Evaluation of novel Brucella melitensis unmarked deletion mutants for safety and efficacy in the goat model of brucellosis. Vaccine. 2006 Jun 12; 24(24); 5169-77. [PubMed: 16697090].
Kahl-McDonagh et al., 2007: Kahl-McDonagh MM, Arenas-Gamboa AM, Ficht TA. Aerosol infection of BALB/c mice with Brucella melitensis and Brucella abortus and protective efficacy against aerosol challenge. Infection and immunity. 2007; 75(10); 4923-4932. [PubMed: 17664263].
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