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Vaccine Detail
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Brucella abortus GroEL Lactococcus lactis recombinant vector vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus GroEL Lactococcus lactis recombinant vector vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009178
- Type: Recombinant vector vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Lactococcus lactis
- Antigen: GroEL heat-shock protein
- Preparation: Genetically modified Lactococcus lactis strains producing Brucella abortus GroEL protein, either intracellularly or secreted; only the secreted form was stably produced. (Miyoshi et al, 2006)
- Description: The study explores a safer vaccination strategy against Brucella abortus by using Lactococcus lactis as a food-grade live vector to deliver the GroEL heat-shock protein antigen. (Miyoshi et al, 2006)
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| Host Response |
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| References |
Miyoshi et al, 2006: Miyoshi A, Bermúdez-Humarán LG, Ribeiro LA, Le Loir Y, Oliveira SC, Langella P, Azevedo V. Heterologous expression of Brucella abortus GroEL heat-shock protein in Lactococcus lactis. Microbial cell factories. 2006 Mar 23; 5; 14. [PubMed: 16556312].
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