• Vaccine Name: live attenuated Brucella abortus bvrS/bvrR mutant vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009175
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Host Species as Laboratory Animal Model: Mus musculus (BALB/c mice)
• Antigen: bvrS/bvrR mutation
• Preparation: Live bvrS/bvrR mutant cells used alone or in combination with wbkA mutant or inactivated bvrS cells or purified S-LPS. (Grilló et al, 2006)
• Description: The bvrS/bvrR mutant is markedly attenuated while keeping a smooth lipopolysaccharide (S-LPS) and was previously shown to be attenuated. Efficacy: The bvrS mutant alone protected against virulent B. abortus but less effectively than when combined with the wbkA mutant; combination provided better protection than B. abortus strain 19 vaccine. Immune response: The bvrS-wbkA combination induced an antibody response reduced compared to B. abortus strain 19 vaccination. (Grilló et al, 2006)

Mouse Response

• Host Strain: BALB/c
• Immune Response: The bvrS-wbkA combination induced an antibody response reduced compared to B. abortus strain 19 vaccination. (Grilló et al, 2006)
• Challenge Protocol: Protection against virulent Brucella abortus challenge in BALB/c mice; measurement of splenic persistence and antibody response. (Grilló et al, 2006)
• Efficacy: The bvrS mutant alone protected against virulent B. abortus but less effectively than when combined with the wbkA mutant; combination provided better protection than B. abortus strain 19 vaccine. (Grilló et al, 2006)
• Description: Protection against virulent Brucella abortus challenge in BALB/c mice; measurement of splenic persistence and antibody response. (Grilló et al, 2006)