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Vaccine Detail
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inactivated Brucella abortus T150R1-adjuvanted vaccine |
| Vaccine Information |
- Vaccine Name: inactivated Brucella abortus T150R1-adjuvanted vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009160
- Type: Inactivated vaccine
- Status: Research
- Host Species for Licensed Use: Chicken
- Host Species as Laboratory Animal Model: Gallus gallus domesticus (chickens)
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Adjuvant:
nionic block polymer T150R1
- Preparation: Oil-in-water emulsions of the nonionic block polymer T150R1 combined with killed Brucella abortus antigen. (Ragland et al, 2004)
- Description: Chickens were injected subcutaneously at one day of age with oil-in-water emulsions containing the nonionic block polymer T150R1. Efficacy: Chickens treated with T150R1 polymer developed higher IgM antibody titers to sheep erythrocytes and killed Brucella abortus compared to untreated controls. Immune response: Increased IgM antibody response; no effect on cell-mediated immunity as measured by blastogenic responses; suggested stimulation of more rapid B cell migration to peripheral organs. (Ragland et al, 2004)
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| Host Response |
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| References |
Ragland et al, 2004: Ragland WL, Hunter RL. Immunomodulation of chickens with the nonionic block polymer T150R1. Immunopharmacology and immunotoxicology. 2004 Feb; 26(1); 125-33. [PubMed: 15106737].
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