• Vaccine Name: live attenuated Brucella abortus per mutant vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009154
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: per gene mutant (perosamine synthetase)
• Preparation: Live attenuated rough lipopolysaccharide mutant with per gene disruption. (Monreal et al, 2003)
• Description: The per mutant was evaluated as a rough vaccine candidate in mice. Efficacy: Induced protection against Brucella abortus but less than the standard smooth vaccine strain 19; afforded similar protection to strain 19 against Brucella ovis. Immune response: Induced antibodies to rough LPS and outer membrane proteins; protection attributed largely to anti O-polysaccharide antibodies. (Monreal et al, 2003)

Mouse Response

• Immune Response: Induced antibodies to rough LPS and outer membrane proteins; protection attributed largely to anti O-polysaccharide antibodies. (Monreal et al, 2003)
• Challenge Protocol: Mouse model challenge experiments. (Monreal et al, 2003)
• Efficacy: Induced protection against Brucella abortus but less than the standard smooth vaccine strain 19; afforded similar protection to strain 19 against Brucella ovis. (Monreal et al, 2003)
• Description: Mouse model challenge experiments. (Monreal et al, 2003)