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Vaccine Detail

manB(core) mutant vaccine

Vaccine Information

Vaccine Name: manB(core) mutant vaccine
Target Pathogen: Brucella spp.
Target Disease: Brucellosis
Vaccine Ontology ID: VO_0009153
Type: Live attenuated vaccine
Status: Research
Host Species for Licensed Use: Cattle
Host Species as Laboratory Animal Model: Mus musculus
Antigen: manB(core) gene mutant (phosphomannomutase)
Preparation: Live attenuated rough lipopolysaccharide mutant with manB(core) gene disruption. (Monreal et al, 2003)
Description: The manB(core) mutant was tested as a rough vaccine candidate in mice. Efficacy: Ineffective as a vaccine against Brucella abortus in mice. Immune response: Induced antibodies to rough LPS and outer membrane proteins but did not confer effective protection. (Monreal et al, 2003)

Host Response

Mouse Response

Immune Response: Induced antibodies to rough LPS and outer membrane proteins but did not confer effective protection. (Monreal et al, 2003)
Challenge Protocol: Mouse model challenge experiments. (Monreal et al, 2003)
Efficacy: Ineffective as a vaccine against Brucella abortus in mice. (Monreal et al, 2003)
Description: Mouse model challenge experiments. (Monreal et al, 2003)

References

Monreal et al, 2003: Monreal D, Grilló MJ, González D, Marín CM, De Miguel MJ, López-Goñi I, Blasco JM, Cloeckaert A, Moriyón I. Characterization of Brucella abortus O-polysaccharide and core lipopolysaccharide mutants and demonstration that a complete core is required for rough vaccines to be efficient against Brucella abortus and Brucella ovis in the mouse model. Infection and immunity. 2003 Jun; 71(6); 3261-71. [PubMed: 12761107].