• Vaccine Name: Brucella abortus BCSP31 Cu-Zn SOD HtrA two-component systems subunit vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009152
• Type: Subunit vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Host Species as Laboratory Animal Model: HeLa cells; macrophage-related cell lines; Mus musculus
• Antigen: BCSP31; Cu-Zn SOD; HtrA; two-component systems
• Preparation: Subunit vaccine containing proteins cloned from salt extract and antigenic or virulence-related proteins. (Halling, 2002)
• Description: Early vaccine development studies included a subunit vaccine prepared by salt extraction of B. abortus. Efficacy: Antigenicity was not predictive of subunit vaccine effectiveness; no clear correlation with protection. (Halling, 2002)

Mouse Response

• Host cell type: HeLa
• Efficacy: Antigenicity was not predictive of subunit vaccine effectiveness; no clear correlation with protection. (Halling, 2002)
• Description: In vitro mammalian cell lines (HeLa and macrophage-related), mouse model, and host animal models. (Halling, 2002)