• Vaccine Name: live attenuated Brucella abortus strain RB51 overexpressing SodC and Ag85A vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009151
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: Cu-Zn superoxide dismutase (SOD); 85A (Mycobacterium spp. protective protein)
• Preparation: Live attenuated RB51 strain genetically modified to overexpress SOD and express 85A protein. (Vemulapalli et al, 2002)
• Description: A recombinant RB51 strain engineered to overexpress Cu-Zn superoxide dismutase and simultaneously express 85A, a protective protein of Mycobacterium spp. Efficacy: Mice vaccinated with RB51SOD/85A showed significantly enhanced protection against Brucella challenge compared to strain RB51 alone. Immune response: Vaccinated mice developed specific immune responses to the mycobacterial 85A protein and a strong Th1 type immune response. (Vemulapalli et al, 2002)

Mouse Response

• Immune Response: Vaccinated mice developed specific immune responses to the mycobacterial 85A protein and a strong Th1 type immune response. (Vemulapalli et al, 2002)
• Challenge Protocol: Mice vaccinated with RB51SOD/85A were evaluated for immune responses and protection against Brucella challenge. (Vemulapalli et al, 2002)
• Efficacy: Mice vaccinated with RB51SOD/85A showed significantly enhanced protection against Brucella challenge compared to strain RB51 alone. (Vemulapalli et al, 2002)
• Description: Mice vaccinated with RB51SOD/85A were evaluated for immune responses and protection against Brucella challenge. (Vemulapalli et al, 2002)