• Vaccine Name: live attenuated Brucella abortus strain RB51 vaccine expressing ESAT-6 fusion protein
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009150
• Type: Live attenuated vaccine
• Status: Research
• Host Species for Licensed Use: Cattle
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: ESAT-6 (Mycobacterium bovis protective protein); Cu-Zn superoxide dismutase signal sequence fusion
• Preparation: Live attenuated RB51 strain genetically modified to express ESAT-6 fusion protein. (Vemulapalli et al, 2002)
• Description: A recombinant RB51 strain expressing ESAT-6, a protective protein of Mycobacterium bovis, as a fusion protein with the signal sequence and additional amino terminal amino acids of SOD. Efficacy: Mice vaccinated with RB51ESAT showed significantly enhanced protection against Brucella challenge compared to strain RB51 alone. Immune response: Vaccinated mice developed specific immune responses to the mycobacterial ESAT-6 protein and a strong Th1 type immune response. (Vemulapalli et al, 2002)

Mouse Response

• Immune Response: Vaccinated mice developed specific immune responses to the mycobacterial ESAT-6 protein and a strong Th1 type immune response. (Vemulapalli et al, 2002)
• Challenge Protocol: Mice vaccinated with RB51ESAT were evaluated for immune responses and protection against Brucella challenge. (Vemulapalli et al, 2002)
• Efficacy: Mice vaccinated with RB51ESAT showed significantly enhanced protection against Brucella challenge compared to strain RB51 alone. (Vemulapalli et al, 2002)
• Description: Mice vaccinated with RB51ESAT were evaluated for immune responses and protection against Brucella challenge. (Vemulapalli et al, 2002)