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Vaccine Detail
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live attenuated Brucella melitensis Omp25 deletion mutant vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella melitensis Omp25 deletion mutant vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009143
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Goat
- Host Species as Laboratory Animal Model: Mus musculus; Capra hircus
- Antigen: Omp25 deletion mutant
- Preparation: Live attenuated Brucella melitensis mutant BM 25 with deletion of Omp25 protein. (Edmonds et al, 2002)
- Description: The Brucella melitensis mutant BM 25 lacks the major 25 kDa outer membrane protein Omp25 and was previously found attenuated in the murine model. This study evaluated its pathogenicity and protective capacity in pregnant goats. Efficacy: Vaccination with BM 25 prior to breeding resulted in 100% protection against abortion following challenge with virulent strain 16M, comparable to protection by strain Rev. 1. Immune response: Not reported explicitly; inferred protective immunity as evidenced by prevention of abortion and colonization without causing abortions. (Edmonds et al, 2002)
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| Host Response |
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| References |
Edmonds et al, 2002: Edmonds MD, Cloeckaert A, Hagius SD, Samartino LE, Fulton WT, Walker JV, Enright FM, Booth NJ, Elzer PH. Pathogenicity and protective activity in pregnant goats of a Brucella melitensis Deltaomp25 deletion mutant. Research in veterinary science. 2002 Jun; 72(3); 235-9. [PubMed: 12076120].
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