• Vaccine Name: Brucella suis O-polysaccharide subunit vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009118
• Type: Subunit vaccine
• Status: Research
• Host Species for Licensed Use: Pig
• Antigen: O-polysaccharide (OPS)
• Preparation: Purified O-polysaccharide at doses of 100 to 500 micrograms; administered intramuscularly or orally; one or three doses. (Lord et al, 1998)
• Description: Purified OPS from Brucella abortus 1119-3 and Brucella suis 1330 were evaluated as vaccines in field trials in Venezuela for protection of swine against Brucella suis challenge. Efficacy: Gilts vaccinated with OPS showed no serologic reactions, no abortions (100% protection), and litter sizes of 10 to 12 pigs. Immune response: No serologic reactions detected in vaccinated gilts, indicating effective protection without detectable antibody response by the assays used. (Lord et al, 1998)

Pig Response

• Immune Response: No serologic reactions detected in vaccinated gilts, indicating effective protection without detectable antibody response by the assays used. (Lord et al, 1998)
• Challenge Protocol: Purified OPS from Brucella abortus 1119-3 and Brucella suis 1330 were evaluated as vaccines in field trials in Venezuela for protection of swine against Brucella suis challenge. (Lord et al, 1998)
• Efficacy: Gilts vaccinated with OPS showed no serologic reactions, no abortions (100% protection), and litter sizes of 10 to 12 pigs. (Lord et al, 1998)
• Description: Vaccination of gilts, mating with infected boars, followed by serologic testing, bacteriologic culture, abortion monitoring, and litter size assessment. (Lord et al, 1998)