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Vaccine Detail
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Brucella abortus BP26 protein vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus BP26 protein vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009110
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Escherichia coli
- Antigen: BP26
- Description: A 26-kDa periplasmic protein (BP26) was cloned from Brucella abortus strain 19 genome and characterized; it is a novel protein with no similarity to previously sequenced genes. Immune response: BP26 protein allowed differentiation between vaccinated and infected bovines and detection of infected rams; sera from human patients with active brucellosis were positive, while sera from chronic or asymptomatic patients were nonreactive, indicating potential diagnostic value. (Rossetti et al, 1996)
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| Host Response |
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| References |
Rossetti et al, 1996: Rossetti OL, Arese AI, Boschiroli ML, Cravero SL. Cloning of Brucella abortus gene and characterization of expressed 26-kilodalton periplasmic protein: potential use for diagnosis. Journal of clinical microbiology. 1996 Jan; 34(1); 165-9. [PubMed: 8748294].
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