• Vaccine Name: Brucella ovis Omp and rough lipopolysaccharide subunit vaccine
• Target Pathogen: Brucella spp.
• Target Disease: Brucellosis
• Vaccine Ontology ID: VO_0009091
• Type: Subunit vaccine
• Status: Research
• Host Species for Licensed Use: Sheep
• Host Species as Laboratory Animal Model: Mus musculus
• Antigen: outer-membrane proteins (16.5-, 25-27-, 31-34- and 36-38-kDa OMPs); rough lipopolysaccharide (R-LPS)
• Preparation: Monoclonal antibodies directed against multiple outer membrane proteins and rough lipopolysaccharide were tested individually and in combination. (Bowden et al, 1995)
• Description: The study aimed to identify protective antigens of Brucella ovis to develop a safe, specific subcellular vaccine for ram epididymitis. Efficacy: Mixtures of MAbs against specific OMPs and anti-R-LPS MAb alone conferred significant protection compared to controls; combination of OMP MAbs with anti-R-LPS MAb was strongly protective. Immune response: Protective antibodies targeted B. ovis outer membrane proteins and rough lipopolysaccharide, indicating these antigens as candidates for subcellular vaccines. (Bowden et al, 1995)

Mouse Response

• Immune Response: Protective antibodies targeted B. ovis outer membrane proteins and rough lipopolysaccharide, indicating these antigens as candidates for subcellular vaccines. (Bowden et al, 1995)
• Challenge Protocol: Mouse protection test using monoclonal antibodies against B. ovis OMPs and R-LPS, with challenge by B. ovis strain 63/290. (Bowden et al, 1995)
• Efficacy: Mixtures of MAbs against specific OMPs and anti-R-LPS MAb alone conferred significant protection compared to controls; combination of OMP MAbs with anti-R-LPS MAb was strongly protective. (Bowden et al, 1995)
• Description: Mouse protection test using monoclonal antibodies against B. ovis OMPs and R-LPS, with challenge by B. ovis strain 63/290. (Bowden et al, 1995)