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Vaccine Detail
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Brucella abortus O-polysaccharide and core oligosaccharide subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus O-polysaccharide and core oligosaccharide subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009089
- Type: Lipopolysaccharide vaccine
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: lipopolysaccharide (LPS) epitopes including O-polysaccharide (A and C), core oligosaccharide (R1 and R2), lipid A (LA1, LA2, LA3), lipid A-associated outer membrane protein (LAOmp3-1 and LAOmp3-2)
- Description: Immune response: Sera from infected and vaccinated bovines recognized multiple LPS determinants; monoclonal antibodies identified nine different LPS epitope specificities; antibodies against rough B. abortus LPS epitopes cross-reacted with smooth LPS; findings relate to the structure and epitopic density of B. abortus LPS (Rojas et al, 1994)
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| Host Response |
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| References |
Rojas et al, 1994: Rojas N, Freer E, Weintraub A, Ramirez M, Lind S, Moreno E. Immunochemical identification of Brucella abortus lipopolysaccharide epitopes. Clinical and diagnostic laboratory immunology. 1994 Mar; 1(2); 206-13. [PubMed: 7496947].
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