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Vaccine Detail
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inactivated Brucella abortus strain 45/20 outer membrane protein vaccine |
| Vaccine Information |
- Vaccine Name: inactivated Brucella abortus strain 45/20 outer membrane protein vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009079
- Type: Inactivated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Antigen: porin; outer membrane proteins; outer membrane; whole cell (rough strain 45/20)
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Adjuvant:
trehalose dimycolate and muramyl dipeptide (N-acetylmuramyl-L-alpha-amibutyryl-D-isoglutamine)
- Preparation: Vaccines contained trehalose dimycolate and a derivative of muramyl dipeptide at fixed doses; antigen types included whole cell, outer membrane, and detergent-extracted outer membrane proteins; mineral oil quantity was varied. (Winter et al, 1983)
- Description: The study evaluated nonliving vaccines derived from Brucella abortus rough strain 45/20 containing porin and other outer membrane protein antigens combined with trehalose dimycolate and muramyl dipeptide adjuvants. Efficacy: Outer membrane proteins induced highest antibody titers; increasing mineral oil improved antibody responses; immune responses sustained longer than 3 months after two vaccinations; no ill effects observed. Immune response: Strong blastogenesis responses to porin, highest antibody titers to porin-lipopolysaccharide complex with outer membrane proteins; delayed-type hypersensitivity reactions observed; immune responses exceeded those after natural or experimental infection. (Winter et al, 1983)
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| Host Response |
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| References |
Winter et al, 1983: Winter AJ, Verstreate DR, Hall CE, Jacobson RH, Castleman WL, Meredith MP, McLaughlin CA. Immune response to porin in cattle immunized with whole cell, outer membrane, and outer membrane protein antigens of Brucella abortus combined with trehalose dimycolate and muramyl dipeptide adjuvants. Infection and immunity. 1983 Dec; 42(3); 1159-67. [PubMed: 6315592].
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