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Vaccine Detail
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purified killed Brucella abortus vaccine from smooth strain 544 |
| Vaccine Information |
- Vaccine Name: purified killed Brucella abortus vaccine from smooth strain 544
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009076
- Type: Inactivated vaccine
- Status: Research
- Host Species for Licensed Use: Human
- Host Species as Laboratory Animal Model: guinea-pigs; Mus musculus
- Preparation: Whole-culture extract; activity enhanced by water-in-oil emulsions; no adjuvant required for immunization in guinea-pigs. (Keppie et al, 1972)
- Description: A purified killed vaccine developed for use in man from the smooth strain 544 and previously tested in mice. Efficacy: Highly active and immunizing in mice and guinea-pigs; immunization in guinea-pigs without adjuvant; activity enhanced by water-in-oil emulsions. Immune response: Produced delayed hypersensitivity in guinea-pigs; highly agglutinogenic compared to rough strain vaccine. (Keppie et al, 1972)
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| Host Response |
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| References |
Keppie et al, 1972: Keppie J, Witt K, Smith H. The immunization of guinea-pigs and mice with a whole-culture extract of a smooth and a rough strain of Brucella abortus. British journal of experimental pathology. 1972 Oct; 53(5); 518-28. [PubMed: 4628447].
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