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Vaccine Detail
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Brucella abortus strain 2308 hot-SDS-insoluble cell-envelope fraction (PG) subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus strain 2308 hot-SDS-insoluble cell-envelope fraction (PG) subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009072
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: insoluble residue of cell envelopes; porin; group 3 proteins; O polysaccharide
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Adjuvant:
oil base adjuvant containing trehalose dimycolate and muramyl dipeptide
- Preparation: Vaccines were administered by injection in an oil base adjuvant containing trehalose dimycolate and muramyl dipeptide or without adjuvant. (Winter et al, 1988)
- Description: A vaccine (PG) composed of the insoluble residue of strain 2308 cell envelopes extracted with hot sodium dodecyl sulfate was compared to native cell envelope vaccines. Efficacy: Mice vaccinated with PG showed protective immunity equivalent to native cell envelope vaccine; in cattle, PG without adjuvant induced negligible immune responses; revaccination with PG in adjuvant enhanced antibody production. Immune response: Both native and PG vaccines stimulated lymphocyte blastogenesis and delayed hypersensitivity to porin and group 3 proteins with no significant difference; PG induced lower antibody responses in cattle unless given with adjuvant. (Winter et al, 1988)
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| Host Response |
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| References |
Winter et al, 1988: Winter AJ, Rowe GE. Comparative immune responses to native cell envelope antigens and the hot sodium dodecyl sulfate insoluble fraction (PG) of Brucella abortus in cattle and mice. Veterinary immunology and immunopathology. 1988 Mar; 18(2); 149-63. [PubMed: 3133872].
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