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Vaccine Detail
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Brucella abortus native cell envelope subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus native cell envelope subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009071
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus
- Antigen: outer membrane proteins; porin; group 3 proteins; O polysaccharide
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Adjuvant:
oil base adjuvant containing trehalose dimycolate and muramyl dipeptide
- Preparation: Vaccines were given by injection in an oil base adjuvant containing trehalose dimycolate and muramyl dipeptide or without adjuvant. (Winter et al, 1988)
- Description: Vaccines composed of native cell envelopes or outer membrane proteins of smooth strain 2308 were compared to a vaccine composed of the insoluble residue (PG) of strain 2308 cell envelopes extracted with hot sodium dodecyl sulfate. Efficacy: Mice vaccinated with native cell envelopes displayed protective immunity equivalent to PG vaccine; in cattle, native cell envelope antigens induced significantly higher titers of whole cell agglutinins over 3 months than PG. Immune response: Both native and PG vaccines stimulated lymphocyte blastogenesis and delayed hypersensitivity to porin and group 3 proteins with no significant difference; native cell envelope vaccine induced higher antibody responses including antibodies to O polysaccharide. (Winter et al, 1988)
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| Host Response |
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| References |
Winter et al, 1988: Winter AJ, Rowe GE. Comparative immune responses to native cell envelope antigens and the hot sodium dodecyl sulfate insoluble fraction (PG) of Brucella abortus in cattle and mice. Veterinary immunology and immunopathology. 1988 Mar; 18(2); 149-63. [PubMed: 3133872].
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