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Vaccine Detail
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Brucella abortus 31-kDa protein subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus 31-kDa protein subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009070
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: rodents; Escherichia coli
- Antigen: 31-kDa protein
- Preparation: Recombinant 31-kDa protein expressed in E. coli from its native promoter; purified protein free of Brucella contaminants. (Mayfield et al, 1988)
- Description: The 31-kDa protein, thought to be localized at or near the bacterial cell surface, was previously shown to protect against experimental brucellosis in rodents. The gene coding for this protein has been cloned and expressed in Escherichia coli, allowing production of the protein free of Brucella contaminants. Efficacy: Preliminary evidence showed protection against experimental brucellosis in rodents by the purified 31-kDa protein. (Mayfield et al, 1988)
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| Host Response |
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| References |
Mayfield et al, 1988: Mayfield JE, Bricker BJ, Godfrey H, Crosby RM, Knight DJ, Halling SM, Balinsky D, Tabatabai LB. The cloning, expression, and nucleotide sequence of a gene coding for an immunogenic Brucella abortus protein. Gene. 1988; 63(1); 1-9. [PubMed: 3133283].
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