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Vaccine Detail
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live attenuated Brucella suis strain S105 vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella suis strain S105 vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009066
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Host Species as Laboratory Animal Model: Mus musculus; guinea pig
- Preparation: Oral vaccine formulation of the mutant strain S105. (Zhao et al, 1989)
- Description: A mutant strain S105 was selected from Brucella suis strain 2 after chemical mutagenesis with diethyl sulphate (DES) to reduce residual virulence. Efficacy: Strain S105 was as effective as the parent strain 2 in stimulating protective immunity to Brucella melitensis in sheep. Immune response: Not reported explicitly; implied protective immunity stimulation in sheep. (Zhao et al, 1989)
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| Host Response |
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| References |
Zhao et al, 1989: Zhao WR, Wendoso, Hasi, Qin YX, Weng W, Lu SL. Selection of a Brucella vaccine strain of low residual virulence by chemical mutagenesis. Journal of medical microbiology. 1989 Oct; 30(2); 143-8. [PubMed: 2795638].
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