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Vaccine Detail
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Brucella melitensis OMPs subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella melitensis OMPs subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009065
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Sheep
- Antigen: proteins of 43 kDa; group A (25.5 to 32.0 kDa); group B (21.5 to 22.5 kDa); group C (18.0 to 19.5 kDa); group D (13.0 to 15.5 kDa)
- Preparation: Subcellular proteins present in hot saline extracts and outer membrane blebs, similar in profile to B. ovis proteins. (Gamazo et al, 1989)
- Description: Proteins extracted by hot saline or released into outer membrane blebs from field strains of Brucella melitensis were analyzed and found to be antigenically related to those of B. ovis. Efficacy: Not directly reported; antigenic similarity and conservation suggest potential for subcellular vaccine development. Immune response: Cross-reactions among strains indicate antigenic relatedness; immunogenic proteins conserved in infected animals. (Gamazo et al, 1989)
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| Host Response |
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| References |
Gamazo et al, 1989: Gamazo C, Winter AJ, Moriyón I, Riezu-Boj JI, Blasco JM, Díaz R. Comparative analyses of proteins extracted by hot saline or released spontaneously into outer membrane blebs from field strains of Brucella ovis and Brucella melitensis. Infection and immunity. 1989 May; 57(5); 1419-26. [PubMed: 2651307].
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