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Vaccine Detail
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live attenuated Brucella abortus BCSP31 deletion vaccine |
| Vaccine Information |
- Vaccine Name: live attenuated Brucella abortus BCSP31 deletion vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009053
- Type: Live attenuated vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: Mus musculus macrophagelike cell line J774; HeLa cells
- Antigen: BCSP31 deletion
- Preparation: Live attenuated Brucella abortus strains with BCSP31 gene deletion constructed by electroporation and recombination; antibiotic-resistant transformants isolated. (Halling et al, 1991)
- Description: The BCSP31 gene encoding a 31-kDa salt-extractable immunogenic protein was deleted from Brucella abortus strains by replacement with an antibiotic resistance marker gene. (Halling et al, 1991)
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| Host Response |
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| References |
Halling et al, 1991: Halling SM, Detilleux PG, Tatum FM, Judge BA, Mayfield JE. Deletion of the BCSP31 gene of Brucella abortus by replacement. Infection and immunity. 1991 Nov; 59(11); 3863-8. [PubMed: 1937745].
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