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Vaccine Detail
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Brucella abortus strain 19 soluble protein extract subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus strain 19 soluble protein extract subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009051
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
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Adjuvant:
dimethyl dioctadecyl ammonium bromide (DDA); trehalose dimycolate (TDM); muramyl dipeptide (MDP)
- Preparation: Soluble protein extract of gamma irradiated Brucella abortus strain 19 (2 mg protein per dose) administered subcutaneously with adjuvants DDA alone, DDA + TDM, or DDA + MDP. (Dzata et al, 1991)
- Description: The study investigated the adjuvant effects of DDA alone or combined with TDM or MDP on immune responses to a soluble protein extract of gamma irradiated Brucella abortus strain 19. Efficacy: The highest and most sustained antibody responses were elicited by the S19 vaccine; among SPEBA groups, SPEBA with DDA + TDM induced higher antibody levels and stronger delayed-type hypersensitivity responses than other adjuvant combinations. Immune response: Minimal humoral responses were induced by SPEBA alone; SPEBA with DDA + TDM induced higher antibody levels, notable delayed-type hypersensitivity, and increased IL-2 production; S19 vaccine induced the greatest IL-2 production and antibody responses; results indicate DDA + TDM combination best potentiated immune responses to the soluble antigen. (Dzata et al, 1991)
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| Host Response |
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| References |
Dzata et al, 1991: Dzata GK, Wyckoff JH, Confer AW. Immunopotentiation of cattle vaccinated with a soluble Brucella abortus antigen with low LPS content: an analysis of cellular and humoral immune responses. Veterinary microbiology. 1991 Sep; 29(1); 15-26. [PubMed: 1835212].
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