|
|
Vaccine Detail
|
Brucella melitensis fraction I subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella melitensis fraction I subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009038
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Macaque
- Host Species as Laboratory Animal Model: Macaca cynomolgus philippinensis
- Antigen: fraction I (soluble antigen)
- Preparation: Purified soluble antigen (fraction I) of Brucella melitensis. (Chen et al, 1976)
- Description: The study investigated vaccination with a soluble antigen (fraction I) of Brucella melitensis. Efficacy: Vaccinated monkeys were protected against subsequent challenge with a virulent strain of Brucella melitensis. Immune response: Both fraction I and Rev. I induced significant antibody titers to Brucella melitensis; transient bacteremia observed in some monkeys. (Chen et al, 1976)
|
| Host Response |
|
|
| References |
Chen et al, 1976: Chen TH, Elberg SS. Priming of Macaca cynomolgus philippinensis with purified antigen of Brucella melitensis before injection of Rev. I vaccine. The Journal of infectious diseases. 1976 Sep; 134(3); 294-6. [PubMed: 824373].
|
|
