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Vaccine Detail
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Brucella abortus strains 19 and 45/20 ribosomal protein subunit vaccine |
| Vaccine Information |
- Vaccine Name: Brucella abortus strains 19 and 45/20 ribosomal protein subunit vaccine
- Target Pathogen: Brucella spp.
- Target Disease: Brucellosis
- Vaccine Ontology ID: VO_0009036
- Type: Subunit vaccine
- Status: Research
- Host Species for Licensed Use: Cattle
- Host Species as Laboratory Animal Model: rabbits; guinea pigs; mice
- Antigen: ribosomal components
- Preparation: Ribosomal preparations free of detectable lipopolysaccharide-protein agglutinogen, containing 2-3 immunodiffusion-reactive components. (Corbel, 1976a)
- Description: Ribosomes were isolated from Brucella abortus strains 19 and 45/20 and studied for their immunological properties. Efficacy: Ribosomes from Brucella abortus S19 induced agglutinins reacting with smooth Brucella strains; those from strain 45/20 induced agglutinins reacting with rough Brucella strains; cattle vaccinated with S19 or 45/20 vaccines developed precipitins to ribosomal components early in the immune response. Immune response: Ribosomal preparations elicited intradermal delayed hypersensitivity reactions in animals infected with Brucella abortus, Brucella melitensis, or Brucella suis; antigenic in rabbits, guinea pigs, and mice; cross-reacted with antisera to multiple Brucella species. (Corbel, 1976a)
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| Host Response |
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| References |
Corbel, 1976a: Corbel MJ. The immunological properties of Brucella ribosomal preparations. Developments in biological standardization. 1976; 31; 115-22. [PubMed: 816681].
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