• Vaccine Name: S. agalactiae BipA Protein Vaccine
• Target Pathogen: Streptococcus agalactiae
• Target Disease: Group B streptococcus (GBS) infection
• Vaccine Ontology ID: VO_0004200
• Type: Subunit vaccine
• Status: Research
• Antigen: Recombinant BipA protein
• BipA gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000139
  • Description: Complete Freund's adjuvant on day 1, incomplete Freund's adjuvant on day 35 (Santi et al., 2009).
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000142
  • Description: Complete Freund's adjuvant on day 1, incomplete Freund's adjuvant on day 35 (Santi et al., 2009).
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: CD‐1
• Vaccination Protocol: Active mouse maternal immunization.A maternal immunization/neonatal pup challenge model of GBS infection was used to verify the protective efficacy of BibA protein in mice. CD‐1 female mice (6–8 weeks old) were immunized intraperitoneally on days 1 (complete Freund’s adjuvant), 21, and 35 (incomplete Freund’s adjuvant) with either PBS or 20 μg of recombinant protein and were then bred 3 days after the last immunization (Santi et al., 2009).
• Challenge Protocol: Within 48 h of birth, pups were injected intraperitoneally with a dose of GBS strain 3050 that would be lethal to 90% of the population, corresponding to 3 x 10^4 colony‐forming units (CFU). Survival of pups was monitored for 3 days after challenge (Santi et al., 2009).
• Efficacy: Immunization of mice with recombinant BibA conferred protection to 69% of the challenged pups (Santi et al., 2009).