• Vaccine Name: P. berghei MSP1 Protein Vaccine
• Target Pathogen: Plasmodium spp.
• Target Disease: Malaria
• Vaccine Ontology ID: VO_0004065
• Type: Subunit vaccine
• Status: Research
• Antigen: Recombinant MSP1 (rPbMSP1)
• MSP1 from P. berghei gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000884
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Lyophilized rPbMSP1 was mixed with alum on the day of injection. Each vaccine formulation, containing 10 ug was administered through IP route to mice .
• Challenge Protocol: For challenge study, mice were intraperitoneally inoculated with parasitized erythrocytes at a density of either 10^6 or 10^5 parasitized
  erythrocytes per mouse (Wan et al., 2007).
• Efficacy: Eight out of ten mice vaccinated with rMSP1 in alum survived challenge with P. berghei (Wan et al., 2007).