• Vaccine Name: S. pyogenes SfbI Protein Vaccine
• Target Pathogen: Streptococcus pyogenes
• Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
• Vaccine Ontology ID: VO_0004056
• Type: Subunit vaccine
• Status: Research
• Antigen: Recombinant SfbI protein
• SfbI gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0001242
• Immunization Route: intranasal immunization

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: MIce were immunized intranasally with 20 μL of SfbI (H2 fragment) covalently coupled to CTB or with CTB alone as a control on days 1, 3, 5, and 26 (30 mg/dose) (Guzmán et al., 1999).
• Challenge Protocol: On day 36 mice were challenged with 10^6 cfu of S. pyogenes DSM 2071 or NS239, respectively (Guzmán et al., 1999).
• Efficacy: SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge (Guzmán et al., 1999).