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Vaccine Detail
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S. pyogenes SfbI Protein Vaccine |
| Vaccine Information |
- Vaccine Name: S. pyogenes SfbI Protein Vaccine
- Target Pathogen: Streptococcus pyogenes
- Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
- Vaccine Ontology ID: VO_0004056
- Type: Subunit vaccine
- Status: Research
- Antigen: Recombinant SfbI protein
- SfbI
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant: cholera toxin B subunit vaccine adjuvant
- Immunization Route: intranasal immunization
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: MIce were immunized intranasally with 20 μL of SfbI (H2 fragment) covalently coupled to CTB or with CTB alone as a control on days 1, 3, 5, and 26 (30 mg/dose) (Guzmán et al., 1999).
- Challenge Protocol: On day 36 mice were challenged with 10^6 cfu of S. pyogenes DSM 2071 or NS239, respectively (Guzmán et al., 1999).
- Efficacy: SfbI-vaccinated animals showed 80% and 90% protection against homologous and heterologous challenge (Guzmán et al., 1999).
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| References |
Guzmán et al., 1999: Guzmán CA, Talay SR, Molinari G, Medina E, Chhatwal GS. Protective immune response against Streptococcus pyogenes in mice after intranasal vaccination with the fibronectin-binding protein SfbI. The Journal of infectious diseases. 1999; 179(4); 901-906. [PubMed: 10068585].
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