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Vaccine Detail

S. pyogenes FbaA Protein Vaccine
Vaccine Information
  • Vaccine Name: S. pyogenes FbaA Protein Vaccine
  • Target Pathogen: Streptococcus pyogenes
  • Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
  • Vaccine Ontology ID: VO_0004054
  • Type: Subunit vaccine
  • Status: Research
  • Antigen: Purified FbaA protein
  • fbaA gene engineering:
    • Type: Recombinant protein preparation
    • Description:
    • Detailed Gene Information: Click Here.
  • Adjuvant:
  • Immunization Route: subcutaneous injection
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were immunized subcutaneously with purified FbaA + Freund’s adjuvant at weeks 0, 2, and 4 (Ma et al., 2009).
  • Challenge Protocol: Mice immunized with FbaA or PBS were injected i.p. with 1 ml bacterial suspension (equivalent to 2 × 10^8 CFU) and monitored
    survival daily for 15 days (Ma et al., 2009).
  • Efficacy: 60% of mice immunized with FbpA were protected from challenge with group A streptococcus (Ma et al., 2009).
  • Host IgG response
    • Description: Assay for immune response showed that FbaA could induce protein-specific high serum IgG titer in BALB/c mice 10 days after injection. There was no significant difference between the antibody titers of the FbaA vaccine and an M protein vaccine, which is the best immugen of group A streptococcus, and FbaA induced significantly higher titers than PBS-vaccinated mice (Ma et al., 2009).
    • Detailed Gene Information: Click Here.
References
Ma et al., 2009: Ma CQ, Li CH, Wang XR, Zeng RH, Yin XL, Feng HD, Wei L. Similar ability of FbaA with M protein to elicit protective immunity against group A streptococcus challenge in mice. Cellular & molecular immunology. 2009; 6(1); 73-77. [PubMed: 19254483].