• Vaccine Name: S. pyogenes FbaA Protein Vaccine
• Target Pathogen: Streptococcus pyogenes
• Target Disease: Group A streptococcal infections, Strep throat, Scarlet fever
• Vaccine Ontology ID: VO_0004054
• Type: Subunit vaccine
• Status: Research
• Antigen: Purified FbaA protein
• fbaA gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000133
• Immunization Route: subcutaneous injection

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: Mice were immunized subcutaneously with purified FbaA + Freund’s adjuvant at weeks 0, 2, and 4 (Ma et al., 2009).
• Challenge Protocol: Mice immunized with FbaA or PBS were injected i.p. with 1 ml bacterial suspension (equivalent to 2 × 10^8 CFU) and monitored
  survival daily for 15 days (Ma et al., 2009).
• Efficacy: 60% of mice immunized with FbpA were protected from challenge with group A streptococcus (Ma et al., 2009).
• Host IgG response
  • Description: Assay for immune response showed that FbaA could induce protein-specific high serum IgG titer in BALB/c mice 10 days after injection. There was no significant difference between the antibody titers of the FbaA vaccine and an M protein vaccine, which is the best immugen of group A streptococcus, and FbaA induced significantly higher titers than PBS-vaccinated mice (Ma et al., 2009).
  • Detailed Gene Information: Click Here.