• Vaccine Name: L. monocytogenes p60 Protein Vaccine
• Target Pathogen: Listeria monocytogenes
• Target Disease: Listeriosis
• Vaccine Ontology ID: VO_0004032
• Type: Subunit vaccine
• Status: Research
• Antigen: p60 protein
• iap gene engineering:
  • Type: Recombinant protein preparation
  • Description:
  • Detailed Gene Information: Click Here.
• Adjuvant:
  • Adjuvant name:
  • VO adjuvant ID: VO_0000366
• Immunization Route: Intraperitoneal injection (i.p.)

Mouse Response

• Host Strain: BALB/c
• Vaccination Protocol: BALB/c mice (two mice/group) were immunized i.p. with 100 μl liposomes containing approximately 3 μg of p60 antigen shown (Grenningloh et al., 2008).
• Challenge Protocol: BALB/c mice were immunized with encapsulated p60 and challenged intravenously on day 9 after immunization with 5 × 10^3 (1 × LD50) L. monocytogenes (Grenningloh et al., 2008).
• Efficacy: Mice immunized with p60 encapsulated in liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes (Grenningloh et al., 2008).