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Vaccine Detail
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B. burgdorferi OspB Protein Vaccine |
| Vaccine Information |
- Vaccine Name: B. burgdorferi OspB Protein Vaccine
- Target Pathogen: Borrelia burgdorferi
- Target Disease: Lyme Disease
- Vaccine Ontology ID: VO_0004029
- Type: Recombinant vector vaccine
- Status: Research
- Antigen: Recombinant OspB protein
- OspB
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant:
- Adjuvant:
- Immunization Route: Intraperitoneal injection (i.p.)
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| Host Response |
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Mouse Response
- Host Strain: C3H/HeN
- Vaccination Protocol: Four-week-old female mice were primed intraperitoneally with 20 μg of each immunogen in 200 μL of complete Freund's adjuvant. Three boosts containing the same amount of immunogen in incomplete Freund's adjuvant were administered at 2, 5, and 8 weeks following the initial injection (Probert and LeFebvre, 1994).
- Challenge Protocol: Ten days following the final boost, mice received a subcutaneous inoculation containing 107 SON 188 organisms in 100 μl of BSK II medium (Probert and LeFebvre, 1994).
- Efficacy: Mice immunized with recombinant OspB protein were protected from challenge with Borrelia burgdorferi (Probert and LeFebvre, 1994).
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| References |
Probert and LeFebvre, 1994: Probert WS, LeFebvre RB. Protection of C3H/HeN mice from challenge with Borrelia burgdorferi through active immunization with OspA, OspB, or OspC, but not with OspD or the 83-kilodalton antigen. Infection and immunity. 1994; 62(5); 1920-1926. [PubMed: 8168958].
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