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Vaccine Detail
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Cancer EPCAM protein vaccine |
| Vaccine Information |
- Vaccine Name: Cancer EPCAM protein vaccine
- Target Pathogen: Cancer
- Target Disease: Cancer
- Vaccine Ontology ID: VO_0011370
- Type: Subunit vaccine
- Status: Research
- Antigen: EPCAM (GA733)
- EPCAM
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: subcutaneous injection
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| Host Response |
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Mouse Response
- Vaccination Protocol: Mice were immunized with 100 lg of Ab2 BR3E4 in CFA/IFA on days 0, 12, and 33, or with 5 lg alum-precipitated GA733-2E on days 0, 14, and 28 (Maruyama et al., 2000).
- Challenge Protocol: Immunized mice (4±6/group) were challenged s.c. with 4 x 10^7 CT26-ALGA710-3H cells expressing the GA733 antigen or with parental, antigen-negative
CT26 cells 2 weeks after the last immunization. Tumors were measured with a caliper twice each week for up to 2 months after the challenge (Maruyama et al., 2000).
- Efficacy: The full-length GA733 (epcam) antigen expressed by recombinant adenovirus inhibited the growth of established tumors in mice (Maruyama et al., 2000).
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| References |
Maruyama et al., 2000: Maruyama H, Zaloudik J, Li W, Sperlagh M, Koido T, Somasundaram R, Scheck S, Prewett M, Herlyn D. Cancer vaccines: single-epitope anti-idiotype vaccine versus multiple-epitope antigen vaccine. Cancer immunology, immunotherapy : CII. 2000; 49(3); 123-132. [PubMed: 10881691].
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