VIOLIN Logo
VO Banner
Search: for Help
About
Introduction
Statistics
VIOLIN News
Your VIOLIN
Register or Login
Submission
Tutorial
Vaccine & Components
Vaxquery
Vaxgen
VBLAST
Protegen
VirmugenDB
DNAVaxDB
CanVaxKB
Vaxjo
Vaxvec
Vevax
Huvax
Cov19VaxKB
Host Responses
VaximmutorDB
VIGET
Vaxafe
Vaxar
Vaxism
Vaccine Literature
VO-SciMiner
Litesearch
Vaxmesh
Vaxlert
Vaccine Design
Vaxign2
Vaxign
Community Efforts
Vaccine Ontology
ICoVax 2012
ICoVax 2013
Advisory Committee
Vaccine Society
Vaxperts
VaxPub
VaxCom
VaxLaw
VaxMedia
VaxMeet
VaxFund
VaxCareer
Data Exchange
V-Utilities
VIOLINML
Help & Documents
Publications
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UM Logo

Vaccine Detail

S. typimurium Vi4072
Vaccine Information
  • Vaccine Name: S. typimurium Vi4072
  • Target Pathogen: Salmonella spp.
  • Target Disease: Salmonellosis
  • Vaccine Ontology ID: VO_0004186
  • Type: Recombinant vector vaccine
  • Status: Research
  • TviB gene engineering:
    • Type: Recombinant vector construction
    • Description:
    • Detailed Gene Information: Click Here.
  • Immunization Route: Orally
Host Response

Mouse Response

  • Host Strain: BALB/c
  • Vaccination Protocol: Mice were immunized orally with 5 x 10^7 recombinant Salmonella Vi4072. As controls, groups of mice were inoculated orally with 5 x 10^7 χ4072(pYA248) or BSG (Cao et al., 1992).
  • Challenge Protocol: At 60 days postimmunization, mice were challenged with virulent S. typhi Ty2 (Cao et al., 1992).
  • Efficacy: Immunization of mice with Vi4072 afforded complete protection against fatal infection with virulent S. typhi Ty2 (Cao et al., 1992).
  • Description: The viaB (tviB) gene coding for the Vi antigen of Salmonella typhi Ty2 was subcloned into expression vector pYA248. The recombinant plasmid was termed SMM202 and transformed into Salmonella typhimurium Vi4072, an attenuated ΔcyaΔcrp mutant (Cao et al., 1992).
References
Cao et al., 1992: Cao Y, Wen Z, Lu D. Construction of a recombinant oral vaccine against Salmonella typhi and Salmonella typhimurium. Infection and immunity. 1992; 60(7); 2823-2827. [PubMed: 1612747].