• Vaccine Name: Lassa Virus Nucleoprotein Subunit Vaccine
• Target Pathogen: Lassa Fever Virus
• Target Disease: Lassa fever
• Vaccine Ontology ID: VO_0011441
• Type: Recombinant vector vaccine
• Status: Research
• LASVsSgp1 nucleoprotein gene engineering:
  • Type: Recombinant vector construction
  • Description:
  • Detailed Gene Information: Click Here.
• Immunization Route: Intradermal injection (i.d.)

Guinea pig Response

• Vaccination Protocol: Control animals received either no vaccine or 10^8 PFU of NYBH vaccinia; vaccinated animals received10^8 PFU of V-LSGPC or V-LSN, or a simultaneous injection with both recombinant vaccinia viruses at separate sites, by intradermal injection of 0.1 ml on the back (Morrison et al., 1989).
• Challenge Protocol: Animals were challenged with 10^4 PFU of guinea-pig-passaged Lassa virus by intraperitoneal inoculation 3 to 4 weeks postvaccination (Morrison et al., 1989).
• Efficacy: Ninety-four percent of the animals vaccinated with V-LSN survived a Lassa virus challenge in which only 14% of unvaccinated animals and 39% of animals vaccinated with the New York Board of Health (NYBH) strain of vaccinia virus survived (Morrison et al., 1989).