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Vaccine Detail
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Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2))) |
| Vaccine Information |
- Vaccine Name: Influenza virus HA protein vaccine (Influenza A virus (A/Fukuoka/C29/85(H3N2)))
- Target Pathogen: Influenza virus
- Target Disease: Influenza (flu)
- Vaccine Ontology ID: VO_0004018
- Type: Subunit vaccine
- Status: Research
- Antigen: Influenza A virus (A/Fukuoka/C29/85(H3N2)) HA hemagglutinin
- HA
gene engineering:
- Type: Recombinant protein preparation
- Description:
- Detailed Gene Information: Click Here.
- Adjuvant:
- Immunization Route: Intranasal
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| Host Response |
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Mouse Response
- Host Strain: BALB/c
- Vaccination Protocol: Mice were anaesthetized by an intraperitoneal injection of amobarbital sodium (0.25 ml of a solution of 1 p.g ml-1) and then immunized by an intranasal inoculation of 10lal phosphate-buffered saline (PBS) containing the required dose of HA vaccine and CTB (Tamura et al., 1989).
- Challenge Protocol: Viral challenge four weeks after intranasal inoculation (Tamura et al., 1989).
- Efficacy: The inoculation of HA vaccine prepared from influenza viruses A/Yamagata/120/86 (H1N1) or A/Fukuoka/C29/85 (H3N2) together with CTB provided partial protection against PR-8 infection in Balb/c mice (Tamura et al., 1989).
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| References |
Tamura et al., 1989: Tamura SI, Samegai Y, Kurata H, Kikuta K, Nagamine T, Aizawa C, Kurata T. Enhancement of protective antibody responses by cholera toxin B subunit inoculated intranasally with influenza vaccine. Vaccine. 1989; 7(3); 257-262. [PubMed: 2781859].
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