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Vaccine Detail

ALVAC-AI-H5(H5N1)
Vaccine Information
  • Vaccine Ontology ID: VO_0004730
  • Type: Recombinant vector vaccine
  • Status: Research
  • Host Species for Licensed Use: Baboon
  • Preparation: Fowlpox (FP)-vectored avian influenza (FP-AI) (Bublot et al., 2010).
  • Immunization Route: Intramuscular injection (i.m.)
Host Response

Ducks Response

  • Vaccine Immune Response Type: VO_0003057
  • Efficacy: Immunogenicity induced by the three poxvirus vectors was comparable, and the FP vector was selected for the other studies. As published previously, there was a strong dose effect of the FP-AI priming on the hemagglutination inhibition (HI) titers induced after the boost with an inactivated vaccine. In contrast, the two tested adjuvants did not significantly increase the activity of FP-AI priming. The heterologous prime-boost regimen given to both Muscovy and Pekin ducklings at 1 and 14 or 21 days of age, respectively, was shown to be at least as immunogenic as two administrations of inactivated vaccines given at 2 and 5 wk of age (Bublot et al., 2010).
References
Bublot et al., 2010: Bublot M, Richard-Mazet A, Chanavat-Bizzini S, Le Gros FX, Duboeuf M, Stoll A, Palfi V, Niqueux E, Guionie O, Dren N. Immunogenicity of poxvirus vector avian influenza vaccines in Muscovy and Pekin ducks. Avian diseases. 2010; 54(1 Suppl); 232-238. [PubMed: 20521637].