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Vaccine Detail
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IBV DNA vaccine pVAX1-16S1/M/N |
| Vaccine Information |
- Vaccine Ontology ID: VO_0004535
- Type: DNA vaccine
- Status: Research
- Host Species as Laboratory Animal Model: Chickens
- Antigen: S1, N, and M proteins of the virulent IBVSX16 strain (Yan et al., 2013)
- M membrane protein
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- N protein
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- S1
gene engineering:
- Type: DNA vaccine construction
- Detailed Gene Information: Click Here.
- Vector: pVAX1 prime, inactivated IBV vaccine boost (Yan et al., 2013)
- Immunization Route: Intramuscular injection (i.m.)
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| Host Response |
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Chicken Response
- Vaccination Protocol: Chickens were immunized with the multivalent DNA vaccine twice and then boosted with an inactivated vaccine once (Yan et al., 2013).
- Immune Response: Antibody titers of the chickens immunized with pVAX1-16S1/M/N were much higher than those of the monovalent groups (p < 0.01) (Yan et al., 2013).
- Efficacy: A protective rate up to 90% was observed in the pVAX1-16S1/M/N group (Yan et al., 2013).
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| References |
Yan et al., 2013: Yan F, Zhao Y, Hu Y, Qiu J, Lei W, Ji W, Li X, Wu Q, Shi X, Li Z. Protection of chickens against infectious bronchitis virus with a multivalent DNA vaccine and boosting with an inactivated vaccine. Journal of veterinary science. 2013; 14(1); 53-60. [PubMed: 23388447].
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